Table 2.

Myocardial Infarction Hazard Ratios (95% CI) in Relation to Any SCH, Severity of SCH, and Presence of TPOAb Among Postmenopausal Women From the Women's Health Initiative Observational Study

Thyroid Condition	Unadjusted Model		Adjusted Model
	n (Case/Cohort)	HR (Unadjusted)a	n (Case/Cohort)	HR (Unadjusted)b	HR (Adjusted)c
Euthyroid	677/2704	1.00 (Referent)	650/2926	1.00 (Referent)	1.00 (Ref)
SCHd	59/223	1.14 (0.84–1.55)	58/217	1.18 (0.87–1.60)	1.05 (0.77–1.44)
Milde	38/155	1.08 (0.74–1.56)	37/151	1.10 (0.75–1.60)	0.99 (0.67–1.46)
Moderate/Severef	21/68	1.28 (0.78–2.11)	21/66	1.35 (0.82–2.22)	1.19 (0.72–1.96)
Moderate/Severe and TPOAb+g	11/51	0.99 (0.51–1.92)	11/49	1.06 (0.55–2.04)	0.90 (0.47–1.74)

SCH is TSH 4.7 mU/L or greater; mild, TSH 4.7 to 6.99 mU/L; moderate/severe, TSH 7.00 mU/L or greater; and TPOAb+, anti-TPOAb are present.

^aSample size is based on entire sample until the respective follow-up time.

^bSample size is based on same observations used in the adjusted model.

^cAdjusted for age (50–64 years, 65–70 years, and 71–79 years), ethnicity (white, black, Hispanic, Asian/Pacific Islander, American Indian, or other), gravidity (never pregnant, 1, 2–4, or 5+), smoking status (never, prior, or current), hormone therapy (never, prior, or current), and alcohol consumption (1 or fewer drinks/wk, 2–6 drinks/wk, or 7+ drinks/wk); covariates were measured at baseline only.

^dAny subclinical hypothyroid vs euthyroid.

^eMild subclinical hypothyroid vs euthyroid (severe category omitted).

^fModerate/severe subclinical hypothyroid vs euthyroid (mild category omitted).

^gModerate/severe and TPOAb positive vs euthyroid (mild and TPOAb negative omitted).