Table 3.
Multivariable Adjusted Hazard Ratios for Myocardial Infarction in Relation to Any SCH, Moderate/Severe SCH, and Presence of TPOAb by Strata of Important Covariates Among Women from the Women's Health Initiative Observational Study
| Covariate | Stratum-Specific, Multivariable-Adjusted Hazard Ratios (95% CI)a |
||
|---|---|---|---|
| SCH | Mod/Sev SCH | Mod/Sev SCH and TPOAb+ | |
| Age, y | |||
| 50–64 | 0.98 (0.52, 1.83) | 1.74 (0.82, 3.70) | 1.37 (0.57, 3.30) |
| 65–70 | 0.99 (0.42, 2.35) | 0.53 (0.13, 2.26) | 0.23 (0.02, 2.07) |
| 71–79 | 1.11 (0.51, 2.39) | 1.27 (0.44, 3.69) | 1.04 (0.27, 4.02) |
| P for interaction | .9 | .16 | .12 |
| Smoking | |||
| Never | 1.11 (0.71, 1.73) | 1.16 (0.55, 2.44) | 0.94 (0.36, 2.46) |
| Past | 1.07 (0.56, 2.03) | 1.12 (0.38, 3.34) | 0.78 (0.17, 3.50) |
| Current | 0.74 (0.21, 2.53) | 1.47 (0.36, 6.07) | 1.11 (0.22, 5.69) |
| P for interaction | .69 | .9 | .89 |
| Ethnicityb | |||
| White | 1.07 (0.78, 1.48) | 1.28 (0.77, 2.13) | 0.93 (0.47, 1.84) |
| Black | 1.88 (0.32, 10.88) | — | — |
| Other | 0.7 (0.14, 3.50) | 0.56 (0.06, 5.11) | 1.02 (0.09, 11.07) |
| P for interactionb | .72 | — | — |
| Alcoholb | |||
| 0 to < 1 drink/wk | 1.00 (0.70, 1.45) | 1.36 (0.79, 2.33) | 0.9 (0.44, 1.83) |
| 1–6 drinks/wk | 1.27 (0.57, 2.84) | 1.15 (0.21, 6.29) | 2.04 (0.33, 12.66) |
| 7+ drinks/wk | 0.97 (0.33, 2.87) | — | — |
| P for interactionb | .9 | — | — |
| Gravidity | |||
| Never pregnant | 1.13 (0.38, 3.39) | 2.47 (0.61, 9.98) | 2.82 (0.57, 13.81) |
| 1 | 1.50 (0.31, 7.27) | 2.15 (0.22, 20.87) | 3.32 (0.28, 39.52) |
| 2–4 | 1.12 (0.35, 3.62) | 1.3 (0.27, 6.11) | 0.78 (0.12, 4.89) |
| 5+ | 0.84 (0.24, 2.98) | 0.73 (0.13, 4.13) | 0.61 (0.08, 4.78) |
| P for interaction | .68 | .33 | .18 |
| Hormone therapy | |||
| Never | 0.94 (0.59, 1.51) | 0.76 (0.34, 1.71) | 0.62 (0.22, 1.73) |
| Past | 1.19 (0.49, 2.90) | 1.21 (0.24, 6.06) | 0.58 (0.05, 6.54) |
| Current | 1.12 (0.56, 2.22) | 1.98 (0.66, 5.92) | 1.66 (0.41, 6.60) |
| P for interaction | .76 | .1 | .2 |
Abbreviations: Mod/Sev, moderate/severe; —, data not collected. SCH is TSH 4.70 mU/L or greater; moderate/severe is TSH 7.00 mU/L or greater; TPOAb+ is anti-TPOAb present.
a
Hazard ratios for each interaction covariate category was mutually adjusted for all other covariates as listed and categorized in the table.
b
Effect estimates and P value for interaction are left blank for certain ethnicity and alcohol categories for the Mod/Sev SCH and Mod/Sev SCH and TPOAb+ groups due to unstable effect estimates.