Figure 3.

Life-table analysis indicating probabilities of initially normal hypothalamic-pituitary-target gland axes remaining normal after radiotherapy (3750–4250 cGy). GH secretion is the most sensitive of the anterior pituitary hormones to effects of external radiotherapy, and GHD precedes development of ACTH, LH, FSH, and TSH hormone deficiencies. [Modified from M. D. Littley et al: Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q J Med. 1989;70:145–160 (82), with permission. © Association of Physicians of Great Britain and Ireland.]