Table 2.

Idiopathic Acquired Adult GHD: Enhancing Diagnostic Precision

Exhaustive History	Age
	Childhood health
	Brain tumor
	Motor vehicle accident or other trauma
	Contact sports
	Cerebrovascular thrombosis or hemorrhage
	Mood disorder
	Hyperparathyroidism
Physical examination	Body weight
	Abdominal obesity
	BMI
Pituitary MRI	Subtle changes
	Partially empty sella
	Stalk integrity
	New lesion development
Biochemical	2 GH stimulation tests
	IGF-I (age-matched)
	Pituitary antibodies

Abbreviation: MRI, magnetic resonance imaging. Listed factors are often subtle clues that may trigger a more precise diagnostic evaluation for GHD.