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. 2013 Feb 14;133(6):1533–1540. doi: 10.1038/jid.2013.4

Figure 4.

Figure 4

Cytotoxic CD8+ T cell does not contribute to parasite killing in cutaneous leishmaniasis (CL) patients. Macrophages from peripheral blood mononuclear cells (PBMC) of CL patients were infected or not infected with parasites and cocultured with autologous lymphocytes or peripheral CD8+ T cells for 48 hours. (a) R1 was analyzed from the CD8 versus forward scatter (FSC) dot plot (top). Histograms are representative of six CL patients. The graph shows the expression of granzyme B in CD8+ T cells. (b, c) Infected macrophages cocultured (closed bars) or not (open bar) with peripheral lymphocytes (b) or with purified CD8+ T cells (closed bars) (c) in the absence or presence of inhibitors. *P<0.05; **P<0.01. Statistical comparisons were done using the Mann–Whitney U-test, the Kruskal–Wallis test, or the Friedman test, followed by the Dunn's multiple comparison test.