Table 1.
Treatment and results for low-grade chondrosarcoma in recent literature
| Author [Ref.] | No. of patients, sites | Diagnosis | Follow-up (months) | Surgical treatment (no. of patients) | Adjuvants (other than cement) | Filling of defect after curettage | Recurrence (%) | Distant metastasis (%) | Postop. fractures (%) | Grade switch after LR |
|---|---|---|---|---|---|---|---|---|---|---|
| Verdegaal et al. [31] | 85 limbs | CS low gr | 86 (2–169) | Curettage | Phenol | Allografts | 5.9 | 0 | 2.3 | 0/5 |
| Funovics et al. [11] | 70 all sites | CS low gr | 81 (6–317) | Resection (36), curettage (34) | None | Cement | Intrales: 17.9, margin: 14.3 | 1.4 | NA | None |
| Andreou et al. [8] | 56 low grade out of 115 all grade, all sites | CS gr 1 | 144 (60–288) (follow-up of entire series, 115 pts) | Curettage or resection | NA | NA | 26.8 | 5.3 | NA | At least 3, NA entire number |
| Donati et al. [14] | 31 limbs | CS gr 1 | 157 (66–296) | Resection (16), curettage (15) | Phenol (9), liquid nitr (3), none (3) | Cement (5), allografts (3), autografts (1), Cem + Pr (2), none (4) | Resection: 0, curettage: 13.3 | 0 | Resect: 0, curett: 6.7 | 0/2 |
| Mohler et al. [22] | 46 all sites | CS gr 1/enchondroma | 47 (18–134) | Curettage | Liquid nitr + H2O2 | Cement | 4.3 | 0 | 6.5 | 0/2 |
| Souna et al. [15] | 15 limbs | CS gr 1 | 96 (60–132) | Curettage | Liquid nitrogen | None | 0 | 0 | 6.7 | – |
| Aarons et al. [16] | 32 limbs | CS gr 1 | 55 (24–203) | Resection (15), curettage (17) | Phenol (6), liquid nitr (3), H2O2 (1), none (7) | Cement (10), allografts (7) | Resection: 6.7, curettage:5.9 | 0 | Resect: 20, curett: 5.9 | 0/2 |
| Hanna et al. [17] | 39 limbs | CS gr 0.5/CS gr 1 | 61 (36–104) | Curettage | None | Cement | 5 | 0 | 0 | 0/2 |
| Van Der Geest et al. [21] | 130 NA | CS gr 1/enchondroma | 60 (24–119) | Curettage | Liquid nitrogen | Allografts or autografts (cement in 3 cases) | 1.5 | 0 | 14 | 0/2 |
| Streitburger et al. [10] | 69 all sites | CS gr 1 | 78.5 (2–365) | Resection (60; wide marg. 43), curettage (9) | H2O2 | Cement (6) | 14.5 | 5.8 | NA | 3/10 |
| Leerapun et al. [13] | 70 limbs | CS gr 1 | 102 (2–273) | Resection (57), curettage (13) | Phenol | Bone graft (12), cement (1) | 2.8 | 2.8 | NA | 1/2 |
| Ahlmann et al. [20] | 10 all sites | CS low gr | 38.5 (24–60) | Curettage | Argon gas cryoprobes | Cement | 0 | 0 | 0 | – |
| Our series | 80 limbs | CS gr 1 | 72 (24–206) | Resection (23), curettage (57) | Phenol (40) | Allografts (53), cement (3), bone substit (1) | Resection: 0, curettage: 3.5 | 0 | Curett: 1.7 | 1/2 |
Cem + Pr: after performing curettage, removal of metaphysis together with the epiphysis, using the removed bone to obtain a cemented composite prosthesis
gr grade, NA not available data, Intrales intralesional margins, Margin marginal margins