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Type of interactions and interacting amino acid residues of COX-2 protein with selected ligands
| COX-2 Protein | H-Bonding | V-waal | Pi-pi | Pi-sigma | Pi-cation |
|---|---|---|---|---|---|
| Cycloprodigiosin | Tyr324 | ----- | Phe487 | ----- | Arg89 |
| Prodigiosin | Leu321, Tyr324 | ----- | ----- | ----- | ----- |
| Rofecoxib | ----- | ----- | ----- | ----- | Arg89 |
| Celecoxib | His58, tyr324, gln161, leu321 | ----- | ----- | ----- | Arg89 |
