Table 2.

Thirteen of the 100 Highest-Powered Single-Nucleotide Polymorphisms (SNPs), According to a Genomewide Screening Analysis with the Family-Based Association Test (FBAT).^*

SNP	Power Rank†	Model‡	No. of Informative Families	P Value on FBAT	Chromosomal Position	Gene
rs6993479	5	Dominant	54	0.004	chr8:71108153
rs1320125	26	Additive	84	0.006	chr2:240936900
rs956133	32	Additive	84	0.043	chr2:215531591	ABCA12
rs37972	38	Additive	88	0.010	chr7:7974034	GLCCI1
rs10933595	43	Additive	80	0.021	chr2:240940495
rs4282162	49	Recessive	55	0.028	chr4:21426819	KCNIP4
rs2804311	61	Recessive	47	0.011	chr9:545631	ANKRD15
rs2644645	83	Dominant	57	0.021	chr5:174828792	SFXN1
rs10496195	92	Recessive	43	0.042	chr2:74928440	HK2
rs7498886	93	Recessive	53	0.049	chr16:60636703	CDH8
rs12446238	94	Recessive	53	0.049	chr16:60632639	CDH8
rs2172706	95	Additive	72	0.003	chr1:152935918
rs624964	100	Dominant	69	0.018	chr10:11271837	CUGBP2

^*Replication results for the 12 SNPs successfully genotyped in the initial three replication cohorts can be found in Table 2 in the Supplementary Appendix; data from the fourth replication cohort, participants in the Childhood Asthma Research and Education Network trials, were made available only after the initial replication analysis and were limited to the rs37972 variant from this table.

^†The data from the genomewide association study were analyzed with the use of the family-based screening algorithm, which ranks SNPs according to power to detect an association without biasing the subsequent FBAT results. After the ranking by power, the traditional FBAT was used to generate the reported P values.

^‡Model refers to the type of genetic model identified as top-powered for the SNP power rank. Since the screening step did not limit the number of statistical comparisons, all three genetic models were ranked according to statistical power for subsequent association analyses.