Figure 4.

SDH inhibition and survival following 3-NP treatment are similar for WT and Rhes KO mice. A, B, SDH activity was measured in mitochondria isolated from cortex (A) and striatum (B) of mice treated with 120 mg/kg 3-NP or PBS for 6 h; n = 3 mice per group, and reactions were performed in triplicate; *p < 0.05, **p < 0.005, ***p < 0.005. C, Kaplan-Meier survival analysis of WT and Rhes KO mice treated with 3-NP starting at 30 mg/kg and increasing 15% daily until death. No significant difference was found between WTs and KOs; n = 11 for WTs, n = 12 for KOs.