Figure 4.

Top: Threat—Safety contrast imaging results. Two significant clusters were identified revealing significant bilateral middle frontal gyrus, medial PFC and dACC activation under Threat compared to Safe conditions. Bottom: Pairwise comparisons of the signal change in the clusters identified. Activation in both clusters was significantly greater under Threat than Safety at both Low and High Load [left middle frontal gyrus: Low Load/Threat—Low Load/Safe: mean difference = 0.153%, S.D = 0.213, t₍₁₇₎ = 3.043, p = 0.007; High Load/Threat—High Load/Safe: mean difference = 0.192%, S.D = 0.183, t₍₁₇₎ = 4.468, p < 0.001; right middle frontal gyrus, medial PFC and dACC cluster: Low Load/Threat—Low Load/Safe: mean difference = 0.149%, S.D = 0.146, t₍₁₇₎ = 4.335, p < 0.001; High Load/Threat—High Load/Safe: mean difference = 0.147%, S.D = 0.132, t₍₁₇₎ = 4.729, p < 0.001]. Error bars display within-subject standard error (Morey, 2008). ^*p < 0.05 (two-tailed).