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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Bioconjug Chem. 2013 Apr 8;24(4):701–711. doi: 10.1021/bc3006896

Figure 1.

Figure 1

Structure of cyclic RGD peptide dimers and their 99mTc complexes. Structure A represents the ternary ligand system, in which tricine and TPPTS are used as coligands to stabilize the 99mTc-HYNIC core. Structure B represents the HYNIC-K(NIC) chelating system with tricine as coligand to complete the octahedral coordination sphere of technetium. In this way, the highly charged TPPTS is eliminated. Structure C represents the (HYNIC)2K chelating system, in which one HYNIC is monodentate and the other is bidentate while tricine is tridentate. The biomolecule (BM) is a cyclic RGD peptide or non-peptide receptor ligand. The small letter “f” in cyclic peptides represents D-phenylalanine.