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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Bioconjug Chem. 2013 Apr 8;24(4):701–711. doi: 10.1021/bc3006896

Figure 2.

Figure 2

The competitive inhibition curves of 125I-echistatin bound to U87MG glioma cells in the presence of increasing concentrations of cyclic RGD peptide. Their IC50 values were calculated to be 47±2, 35±2, 37±2, 85±1 and 422±15 nM for K(HYNIC)2-2P-RGD2, K(HYNIC)2-3P-RGD2, K(HYNIC)2-3G-RGD2, K(HYNIC)2-RGD2 and c(RGDyK), respectively. The integrin αvβ3 binding affinity follows the order: K(HYNIC)2-3G-RGD2 ~ K(HYNIC)2-2P-RGD2 ~ K(HYNIC)2-3P-RGD2 > K(HYNIC)2-RGD2 ≫ c(RGDfK).