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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Bioconjug Chem. 2013 Apr 8;24(4):701–711. doi: 10.1021/bc3006896

Figure 5.

Figure 5

A: Comparison of 60-min biodistribution data for [99mTc((HYNIC)2K-3P-RGD2)(tricine)] (4: n = 6), [99mTc(HYNIC-3P-RGD2)(tricine)] (5: n = 6) and [99mTc((HYNIC)K(NIC)-3P-RGD2)(tricine)] (6: n = 4) in athymic nude mice bearing U87MG glioma xenografts to show the impact of 99mTc chelate on biodistribution properties of 99mTc radiotracers. B: Comparison of the selected 60-min biodistribution data of 4 in athymic nude mice (n = 6) bearing U87MG glioma xenografts in the absence/presence of excess E[c(RGDfK)]2 (RGD2: 350 μg/mouse or 14 mg/kg) to demonstrate its specificity in binding to integrin αvβ3.