Table 2.

Selected biodistribution data of 1 – 5 in athymic nude mice bearing U87MG human glioma xenografts at 1 h p.i.

Compound	1 (n = 6)	2 (n = 4)	3 (n = 4)	4 (n = 6)	5 (n =6)
Blood	0.81 ± 0.04	0.73 ± 0.15	0.99 ± 0.04	0.69 ± 0.16	0.47 ± 0.06
Brain	0.12 ± 0.01	0.13 ± 0.03	0.14 ± 0.03	0.14 ± 0.02	0.17 ± 0.03
Eyes	0.98 ± 0.09	0.92 ± 0.19	1.27 ± 0.18	1.09 ± 0.21	1.40 ± 0.13
Heart	1.02 ± 0.06	1.06 ± 0.22	1.28 ± 0.30	1.12 ± 0.18	1.67 ± 0.15
Intestine	9.29 ± 1.66	6.87 ± 2.98	11.40 ± 0.97	10.30 ± 5.01	9.45 ± 1.31
Kidneys	12.21 ± 0.93	8.49 ± 1.28	9.94 ± 1.65	9.28 ± 1.14	12.28 ± 1.09
Liver	1.55 ± 0.27	2.61 ± 0.59	2.74 ± 0.50	3.05 ± 0.54	2.92 ± 0.77
Lungs	2.70 ± 0.04	3.17 ± 0.50	2.93 ± 0.65	2.68 ± 0.40	4.25 ± 0.63
Muscle	0.92 ± 0.11	0.79 ± 0.15	1.10 ± 0.32	0.85 ± 0.11	1.12 ± 0.15
Spleen	1.57 ± 0.17	1.74 ± 0.98	1.78 ± 0.26	1.92 ± 0.38	3.11 ± 0.18
Tumor	3.78 ± 0.81	7.46 ± 1.68	9.74 ± 1.65	8.59 ± 1.52	7.24 ± 0.95
Tumor/Blood	4.70 ± 1.22	10.88 ± 0.82	9.87 ± 1.65	15.88 ± 2.87	15.36 ± 1.01
Tumor/Liver	2.43 ± 0.21	2.92 ± 0.64	3.66 ± 0.13	2.98 ± 0.18	2.55 ± 0.36
Tumor/Lung	1.40 ± 0.28	2.52 ± 0.18	3.60 ± 0.13	3.30 ± 0.14	1.71 ± 0.05
Tumor/Muscle	4.23 ± 1.27	9.64 ± 0.46	8.68 ± 1.84	10.76 ± 1.92	6.58 ± 1.58