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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: J Am Chem Soc. 2013 Apr 19;135(17):6442–6445. doi: 10.1021/ja402933s

Table 1.

Organocatalytic Diels–Alder/Cyclization Cascade

graphic file with name nihms471172u1.jpg
entry HX temp (°C) time (h) % yielda % eeb
1 HClO4 0 4 38 88
2 HCl 0 4 25 73
3 HBF4 0 4 71 93
4 HBF4 −10 6 75 94
5c HBF4 −10 6 62 94
6 HBF4 −20 6 73 (70)d 95
a

Yield based on SFC analysis relative to an internal standard.

b

Determined by SFC analysis.

c

Reaction run with 5% v/v water.

d

Isolated yield.