Fig. 2.

Flow diagram illustrating the processing steps in the unbiased DBM pipeline used in this study. Processing begins (top) with global registration of the serial image pair that consists of an ROI around the HF, which corresponds to the ROI-RIGID approach. Whole brain images can instead be used for the traditional WB-RIGID approach. The shaded area on the left shows processing used in 3D deformable mapping and is the same for T1- and HF-MRI. The shaded area on the right shows processing used in 2D deformable mapping, which is only used for HF-MRI. The baseline segmentation image is assumed to be already in the space of the DBM modality. The entire pipeline is repeated for left and right HF. See text for detailed description of each step.