Table 1.

Estimates of annualized atrophy rate in whole hippocampus as defined in Eq. (4) using different DBM configurations. Configurations with the strongest effect sizes in both modalities are indicated in bold.

Expt. no.	DBM modalitya	Labeling modalityb	Global registration	Deformable registration	Control atrophy rate % μ(σ)	Patient atrophy rate % μ(σ)c	Effect size Δ	Sample size N
1	T1-MRI	T1-MRI	WB-RIGID	3D	0.59 (1.38)	1.55 (1.22) *	0.78	325
2	T1-MRI	HF-MRI	WB-RIGID	3D	0.40 (1.51)	1.20 (1.46) n.s.	0.56	661
3	T1-MRI	T1-MRI	ROI-RIGID	3D	0.55 (1.35)	1.50 (1.28)*	0.74	358
4	T1-MRI	HF-MRI	ROI-RIGID	3D	0.35 (1.50)	1.20 (1.42)*	0.60	556
5	HF-MRI	HF-MRI	WB-RIGID	3D	0.17 (0.93)	1.29 (1.37)**	0.82	298
6	HF-MRI	HF-MRI	ROI-RIGID	3D	0.17 (0.88)	1.18 (1.30)**	0.78	326
7	HF-MRI	HF-MRI	WB-RIGID	2D	0.36 (1.01)	1.18 (1.00)**	0.82	293
8	HF-MRI	HF-MRI	ROI-RIGID	2D	0.36 (1.11)	1.26 (1.04)**	0.86	269

^aModality where atrophy rate is measured with DBM.

^bModality where the segmentation of the HF is performed (slightly different anatomical definitions and longitudinal extents of the HF are used in HF-MRI and T1-MRI segmentation protocols).

^cResult of one-sided two sample t-test (patient atrophy rate>control):

^*p<0.05

^**p<0.01, n.s.=not significant.