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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Hypertension. 2013 Feb 4;61(4):921–930. doi: 10.1161/HYPERTENSIONAHA.111.199588

Figure 5. SiRNA mediated knockdown of Src kinase attenuates migration and proliferation in NEP−/− PASMCs.

Figure 5

NEP+/+ and −/− PASMCs were treated with Src siRNA (10nM for 48h), and effects on migration and proliferation was measured (Panels A and B). Effect of Src kinase knockdown on phospho- and total levels of PDGFR, Src and PTEN at baseline is shown in Panel C. Panel D shows quantitation of p-PDGFR and p-PTEN in NEP−/− PASMCs compared to +/+ cells from 3 different paired isolates at baseline. *p≤ 0.05 for comparisons of control to Src siRNA (n=3).