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. Author manuscript; available in PMC: 2013 May 30.
Published in final edited form as: Am J Transplant. 2011 Nov 9;12(2):313–321. doi: 10.1111/j.1600-6143.2011.03836.x

Figure 4. Effect of NK depletion on DSA (HB13) induced CAV and lack of CAV with F(ab’)2fragments of HB13.

Figure 4

A second anti-H-2Kk IgG2a DSA (HB13) given to B6.RAG1−/− recipients with B10.BR hearts induces CAV of comparable severity to 36–7–5 DSA, as judged by the neointimal thickness. Addition of anti-NK1.1 mAb during administration of the HB13 DSA eliminates coronary lesions (p < 0.05). The severity of coronary lesions from animals treated with F(ab’)2 fragment of HB13, one dose of anti-H-2Kk IgG2a DSA (HB13), one dose of anti-H-2Kk IgG2a DSA (HB13) plus F(ab’) of anti-H-2Kk IgG2a DSA (HB13) significantly were lower than that of intact HB13 (p < 0.05, p < 0.01 and p < 0.01, respectively). No lesions are seen in B6.RAG1−/− isografts in response to HB13. Annotation as in Figure 1.