Table 2.
Genome-Wide Meta-analysis Results of Fully Adjusted Model for Single-Nucleotide Polymorphisms with P ≤ 10–8 Excluding the APOE Regiona,b
| Gene | SNP | Chromosome | Base-Pair Position | Function | Allele 1 | Allele 2 | MAF | OR (95% CI) | P Value |
|---|---|---|---|---|---|---|---|---|---|
| ABCA7 | rs115550680 | 19 | 1 050 420 | Intron | G | A | 0.07 | 1.79 (1.47-2.12) | 2.21× 10–9 |
| HMHA1 | rs115553053 | 19 | 1082 844 | Coding-synonymous | T | C | 0.06 | 1.86 (1.49-2.32) | 3.14 × 10–8 |
| GRIN3B | rs115882880 | 19 | 1 001 777 | Intron | A | C | 0.11 | 1.55 (1.32-1.81) | 6.34 × 10–8 |
| – | rs145848414 | 5 | 174 014 114 | Intergenic | A | G | 0.04 | 2.29 (1.69-3.09) | 6.90 × 10–8 |
Abbreviations: MAF, minor allele frequency; OR, odds ratio; SNP, single-nucleotide polymorphism.
a
Adjusted for age, sex, APOE genotype, and population stratification.
b
Odds ratio greater than 1 for all data sets except Mirage300k and Mirage660k, which were not included in the meta-analyses because rs145848414 on chromosome 5 did not pass the minor allele frequency cutoff during the postimputation quality control. The direction of effects in the individual data sets is in the following order: ACT, ADC1 + 2, ADC3, CHAP, ADGC, GenerAAtions, Indianapolis, NIA-LOAD/NCRAD, Mirage300k, Mirage660k.