Table 3.

Difference in BMI per 10 points of the weighted GRS according to the quintiles of physical activity

	Quintiles of physical activity					P for interaction
	Q1	Q2	Q3	Q4	Q5
Women
METs/wk	0-2.4	2.5-5.5	5.5-11.6	11.7-22.9	≥23.0
n	1716	1506	1491	1473	1421
GRS (range)	16.8-41.8	14.8-42.3	16.0-40.2	13.1-42.4	17.9-43.4
β (SE)*
1986-1988†	1.8 (0.3)	1.8 (0.3)	1.6 (0.3)	1.5 (0.3)	1.2 (0.3)	0.001
1986-1996‡	2.1 (0.3)	1.7 (0.2)	1.6 (0.2)	1.3 (0.2)	1.3 (0.2)	0.001
Men
METs/wk	0-2.7	2.8-7.6	7.7-16.2	16.3-31.3	≥31.4
n	918	925	885	916	900
GRS (range)	16.6-40.6	17.1-39.9	18.3-40.8	16.9-41.9	16.0-41.3
β (SE)*
1986-1988†	1.2 (0.3)	0.7 (0.3)	0.7 (0.3)	1.0 (0.2)	0.6 (0.3)	0.001
1986-1996‡	1.5 (0.3)	0.7 (0.2)	0.8 (0.2)	1.0 (0.2)	0.5 (0.2)	0.03
Pooled β (SE) * §
1986-1988†	1.5 (0.2)	1.3 (0.2)	1.2 (0.2)	1.2 (0.2)	0.8 (0.2)	<0.001
1986-1996‡	1.8 (0.2)	1.2 (0.2)	1.2 (0.2)	1.1 (0.1)	0.8 (0.1)	<0.001

^*Difference in BMI (kg/m²) per 10 points of the weighted GRS, adjusted for age, genotype data source, and disease status.

^†Data are based on first 2 year of follow-up after the assessment of physical activity in women and men (1986-1988).

^‡Data are based on 10 years of follow-up in women and men (1986-1996, repeated measures analysis)

^§Results were pooled between women and men by inverse-variance–weighted, fixed-effects meta-analyses.