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. Author manuscript; available in PMC: 2013 May 30.
Published in final edited form as: Clin Pharmacol Ther. 2012 May 16;92(1):103–111. doi: 10.1038/clpt.2012.34

Figure 6.

Figure 6

Determination of endogenous markers of hepatic metabolism. (a,b) The ratio of 4β-hydroxycholesterol/cholesterol and the plasma bilirubin levels were determined at several time points. *P < 0.05, ANOVA, n = 12. The changes in (c) 4β-hydroxycholesterol and (d) total bilirubin levels and the change in (e) CYP2B6 expression in PBMCs were correlated with changes in efavirenz AUC assessed after a single dose and during steady state, respectively. Pearson regression; P value of F test. AUC, area under the curve; EFA, efavirenz; EZE, ezetimibe; PBMC, peripheral blood mononuclear cell.