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. Author manuscript; available in PMC: 2013 May 30.
Published in final edited form as: Clin Pharmacol Ther. 2012 May 16;92(1):103–111. doi: 10.1038/clpt.2012.34

Table 1.

Pharmacokinetic data of efavirenz with and without comedication of ezetimibe in 12 healthy subjects (arithmetic means ± SD are given; *P < 0.0166 for comparison with single dose, Wilcoxon test, Bonferroni adjusted)

Efavirenz single dose Efavirenz single dose + ezetimibe P value Efavirenz steady state + ezetimibe P value
AUC0–24 h μg × h/ml 6.71 ± 2.34 6.21 ± 2.22 0.433 11.4 ± 4.64* 0.010
AUC0–120 h μg × h/ml 17.0 ± 6.39 16.1 ± 6.01 0.388
AUC0–∞ μg × h/ml 29.7 ± 15.4 27.0 ± 12.2 0.814 11.4 ± 4.64* 0.002
C max μg/ml 0.622 ± 0.244 0.659 ± 0.395 0.685 0.918 ± 0.342* 0.005
T max h 2.4 ± 1.9 2.6 ± 1.5 0.824 3.5 ± 3.3 0.152
t ½ h 121 ± 97.0 106 ± 49.3 0.937 54.9 ± 18.9 0.023
CLR free ml/min 0.062 ± 0.031 0.060 ± 0.026 0.594 0.062 ± 0.020 0.013
CLR gluc ml/min 0.050 ± 0.054 0.037 ± 0.030 0.859 0.006 ± 0.013 0.022

AUC, area under the curve; Cmax, maximum concentration in plasma; CLR, renal clearance; Tmax, time point of Cmax; t½, half-life.