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The antinociceptive activity of the cyclic tetrapeptides was assessed in vivo following i.c.v. administration in the 55°C warm-water tail-withdrawal assay in C57Bl/6J mice. All points represent antinociception at peak response, which was 20 min (for 4), 30 min (for peptides 1, 2 and 5) or 40 min (peptide 3). All points represent average % antinociception ± SEM from 7-8 mice. Data for 1 from reference [12a].
