Figure 1.

Myeloid-specific deletion of p38α protects mice from diffuse brain injury-induced vestibulomotor impairments and synaptic protein loss. A, Injured WT mice (mFPI WT) demonstrated significant impairments in rotarod performance compared with sham-injured mice and mFPI p38α KO mice. The injured KO mice were not significantly different from the sham mice. B, Although the differences did not reach statistical significance, at 7 d after injury, levels of the synaptic proteins PSD95 and synaptophysin (SYP) were decreased in the WT mice compared with sham, whereas the injury-induced decrease was not seen in the KO mice; n = 8–14 per group. *p < 0.05, sham versus mFPI WT. **p < 0.01, sham versus mFPI WT. ^#p < 0.05, mFPI WT versus mFPI KO.