Figure 3.

The increase in p-p38 after diffuse brain injury is associated with myeloid cells. A, p-p38 IHC was seen in the WT mFPI mice at 6 h and 7 d post-injury (p.i.) but was nearly absent in the sham-injured mice and the p38α KO mFPI mice. B, Quantification shows a significant increase in the number of p-p38⁺ cells in the injured WT mice at 6 h, which persists to 7 d after injury. Injured p38α KO mice show little to no p-p38 immunoreactivity and are not different from sham-injured mice at either time point (n = 6–12 per group). *p < 0.05. **p < 0.01.