Figure 9.

Myeloid-deficient p38α KO mice have a limited increase in CD45, but similar changes in GR1⁺ monocytes/neutrophils, compared with WT mice. A, Representative photomicrographs of CD45⁺ IHC in the cortex 6 h post-injury (p.i.). B, A significant increase in CD45⁺ staining was found in the cortex of WT mFPI mice compared with sham-injured mice, whereas p38α KO mice showed very little increase in CD45⁺ staining. C, The number of GR1⁺ cells were counted in the cortex and presented as the average number of GR1⁺ cells per coronal tissue section. WT and KO mice showed similar numbers of GR1⁺ cells after injury (n = 6–12 per group). *p < 0.05. **p < 0.01. ***p < 0.001.