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Summary of treatment effect on endogenous ATP7A (or CD8-LL4) subcellular localization.
| Protein | Treatment | Control | Dynasore | Dynamin K44A | AP-1 siRNA | AP-2 siRNA | Clathrin siRNA | AP180-C | Rab22a Q64L |
|---|---|---|---|---|---|---|---|---|---|
| CD8-LL4 | No copper | Vesicles/perinuclear | – | – | – | PM | PM | – | – |
| ATP7A | No copper | TGN | – | TGN | Diffuse | TGN | PM | PM | Puncta |
| ↑copper | PM | – | PM | PM | PM | PM | PM | Puncta | |
| ↑copper/washout | TGN | PM | TGN | Diffuse | PM | PM | PM | Puncta |
–, not done.
