Table 2. Expression of the five factors in tumors and peritumoral tissue in HCC.
| Protein level (cohort 1, n = 182) | |||
| Tumor tissue | Peritumoral tissue | p | |
| VEGF-A | 61352.4±6574.1a | 116769.2±66781.5a | 0.000 |
| VEGFR-1 | 563672.3±212032.5 | 787402.3±211323.4 | 0.002 |
| VEGFR-2 | 23234.7±7342.2 | 586098.5±21211.2 | 0.000 |
| VEGF-C | 2554342.4±143453.2 | 4281456.5±234654.2 | 0.004 |
| VEGFR-3 | 1526352.6±252564.2 | 2240063.4±343563.5 | 0.003 |
| mRNA level (independent cohort 2, n = 45) | |||
| VEGF-A | −7.3±0.13b | −4.5±0.23b | 0.003 |
| VEGFR-1 | −4.1±0.09 | −2.7±0.11 | 0.001 |
| VEGFR-2 | −11.3±0.23 | −3.5±0.13 | 0.000 |
| VEGF-C | −9.2±0.17 | −6.0±0.22 | 0.005 |
| VEGFR-3 | −10.3±0.26 | −8.5±0.17 | 0.000 |
a
Values were measured as integrated optical density (IOD).
b
Values were expressed as –△CT = [CT (factor) –CT (β-actin)].
Abbreviations: VEGF, vascular endothelial growth factor; VEGFR, VEGF receptor.