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. 2013 May 30;8(5):e65898. doi: 10.1371/journal.pone.0065898

Figure 5. CNF1 treatment diminished IL-1β in the hippocampus of apoE4 mice.

Figure 5

Hippocampal (Hip) and cortical (Cx) samples from apoE3 and apoE4 mice, treated with saline or CNF1, were analyzed by ELISA. A. Graph showing IL-1β levels: CNF1 was able to significantly decrease IL-1β levels in the hippocampus of apoE4 mice to values comparable to those of ApoE3 mice, while having no effect in apoE3 healthy mice. B. Graph showing IL-6 levels: CNF1 was not able to mofify IL-6 amount either in hippocampus or in frontal cortex of apoE3 and apoE4 mice. Data are shown as mean ± SEM (pg/ml). Sal-apoE3 mice were used as reference. *p<0.05 vs sal-apoE4; ***p<0.001 vs sal-apoE4, a p<0.05 sal-apoE3 vs CNF1-apoE3; n = 7 per group.