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. 2013 May 30;8(5):e65898. doi: 10.1371/journal.pone.0065898

Figure 6. CNF1 treatment diminished Aβ42 levels in the hippocampus of apoE4 mice.

Figure 6

Hippocampal (Hip) and frontal cortex (Cx) samples from apoE3 and apoE4 mice treated with saline or CNF1 were analyzed by ELISA. CNF1 treatment in apoE4 resulted in a significant decrease in the levels of Aβ42 to apoE3 level. No CNF1 effect was observed in apoE3 mice. CNF1 did not induce significant changes in Aβ42 levels in apoE3 and apoE4 cortex. Data are shown as mean ± SEM (pg/ml). Sal-ApoE3 mice were used as reference. *p<0.05 vs sal-apoE4; ***p<0.001 vs sal-apoE4, a p<0.05 sal-apoE3 vs CNF1-apoE3; n = 7 per group.