Table 2. Toxicities Reported in > 5% of Patients, All Grades (n = 72), Number of Patients (%).
| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Total |
|---|---|---|---|---|---|
|
Hematologic | |||||
| Thrombocytopenia |
10 (14%) |
14 (19%) |
13 (18%) |
2 (3%) |
39 (54%) |
| Anemia |
9 (13%) |
21 (29%) |
4 (6%) |
1 (1%) |
35 (49%) |
| Neutropenia |
3 (4%) |
8 (11%) |
12 (17%) |
2 (3%) |
25 (35%) |
| Leukopenia |
4 (6%) |
8 (11%) |
8 (11%) |
1 (1%) |
21 (29%) |
|
Non-hematologic | |||||
| Fatigue |
11 (15%) |
19 (26%) |
5 (7%) |
0 |
35 (49%) |
| Nausea |
11 (15%) |
12 (17%) |
1 (1%) |
0 |
24 (33%) |
| Venous thromboembolism |
0 |
5 (7%) |
13 (18%) |
2 (3%) |
20 (28%) |
| Anorexia |
4 (6%) |
11 (15%) |
0 |
0 |
15 (21%) |
| Constipation |
5 (7%) |
9 (13%) |
0 |
0 |
14 (19%) |
| Rash/desquamation |
7 (10%) |
4 (6%) |
3 (4%) |
0 |
14 (19%) |
| Diarrhea |
8 (11%) |
3 (4%) |
2 (3%) |
0 |
13 (18%) |
| Vomiting |
3 (4%) |
6 (8%) |
1 (1%) |
0 |
12 (17%) |
| Dehydration |
5 (7%) |
3 (4%) 0 |
8 (11%) |
|
|
| ALT, SGPT (increased) |
3 (4%) |
2 (3%) |
2 (3%) |
0 |
7 (10%) |
| AST, SGOT (increased) |
2 (3%) |
3 (4%) |
1 (1%) |
0 |
6 (8%) |
| Dizziness |
5 (7%) |
1 (1%) |
0 |
0 |
6 (8%) |
| Chills |
4 (6%) |
1 (1%) |
0 |
0 |
5 (7%) |
| Edema, lower limbs |
1 (1%) |
4 (6%) |
0 |
0 |
5 (7%) |
| Confusion |
1 (1%) |
2 (3%) |
1 (1%) |
0 |
4 (6%) |
| Treatment-related hospitalizations |
17 |
||||
| Treatment-related deaths | 0 | ||||