Figure 1. Exon usage influences PKC-mediated C-terminal phosphorylation (note that phosphorylation was not assayed in this study, but was inferred from a Ser to Ala mutation analysis); in turn, C-terminal phosphorylation increases current in long N-terminal splice variants. Four combinations shown: long vs. short N-terminus or L_I-II. PKC and Gβγ bind to all N-terminal variants, and oppose PKC effects albeit more efficaciously in short N-terminal variants. Long L_I-II partially compensates for short N-terminal.