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Figure 5. Quinidine blockage hinders inactivation. (A) Left panel, superimposed Ik evoked by a 0mV/7sec pulse either in control 5 Ko+ or in 5 Ko+ + 0.03 mM Qd (trace labeled Qd) solutions. Right panel: IK with Qd scaled to control peak IK. (B) Extent of inactivation vs. [Qd]. The extent of inactivation was evaluated from traces as in (A), as: 1-(Iend/Ipeak), where Ipeak is peak IK and Iend is IK at pulse end.
