Table 1. Kinetic model rate constants.
Rate constants in s−1 @ 0 mV | Charge (in eo) |
---|---|
ko = 700 k1 = 50 q = 2.2 q’ = 0.1 p = 0.05 p’ = 0.06 s2 = 35 s−2 = 0.3 k = 240 k’ = 130 s1 = 0.03 s−1 = 0.1 s3 = 3 s−3 = 7 |
0.7 −0.9 0.7 −0.6 0.1 0.2 0 0 0.5 −0.5 0.1 −0.1 0 0 |
Model rate constants. (A) The voltage-dependence of rate constants is implemented in the model as exponential equations of the form: ki(V)=ki(0)exp(ziV / kT), where ki(V) is the rate constant at voltage V, ki(0) is its value at 0 mV, zi is the charge associated with the transition and k and T are Boltzmann’s constant and the temperature in °K. (B) The value of the allosteric factor D is taken to be 0.3.