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. 2013 May 1;2(5):e24065. doi: 10.4161/onci.24065

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Figure 1. Mechanism by which tumor cells resist adaptive immune responses. Activated CD8+ T cells expressing the PD-1 receptor are recruited to the tumor and become activated to secrete interferon γ (IFNγ). The local production of IFNγ induces the expression of PD-L1 on the surface of tumor cells, resulting in the delivery of a PD-1-transduced, immunosuppressive signal to CD8+ T cells that drives anergy.