Table 1. Potential vaccines against substances of abuse.
| Drug / Vaccine | Construction of the vaccine | Company |
|---|---|---|
|
Opiates (morphine/heroin) | ||
| - |
Ester-linked morphine tetanus toxoid; Conjugate with keyhole limpet hemocyanin (KLH) |
- |
|
Methamphetamine | ||
| - |
Various conjugates with keyhole limpet hemocyanin (KLH) or outer membrane protein complex (OMPC) (e.g., KLH-S-Meth, OMPC-S-Meths) |
- |
|
Cocaine | ||
| TA-CD |
Conjugate with deactivated cholera toxin B subunit protein combined with human adjuvant alum |
Celtic Pharmaceuticals |
|
Nicotine | ||
| NicVAX |
3-AmNic-rEPA (3′-aminomethylnicotine Pseudomonas aeruginosa r-exoprotein A) |
GlaxoSmithKline/Nabi Biopharmaceuticals |
| TA-NIC |
Nicotine butyric acid covalently linked to recombinant cholera toxin B |
Celtic Pharmaceuticals |
| NIC002 |
Recombinantly produced virus-like protein |
Cytos Biotechnology/Novartis |
| Niccine |
N/A |
Independent Pharmaceutica |
| SEL-068 | Synthetically engineered nanoparticle | Selecta Biosciences Inc. |