Figure 1. Biologic characteristics of transgenic plant-expressed HPV16L1 and LT-B. (A) Extracted protein from HPV16L1-transformed plants shows 50~60 nm hollow spherical particles when observed by electron micrograph (50000x), which are consistent with HPV16 VLPs (arrows). (B) The capacity of plant-derived LT-B binding to GM1 ganglioside. (C) The histology of intestine mucous membrane after oral LT administration (HE20x). The intestinal villus appears normal in the LT-B group, but is heavily swollen and dropsical in the control group. (D) The weight of small intestine from mice after administration of LT orally. *p < 0.05 vs. control group.