Table 2.

Longitudinal Change in Regional Cerebral Volumes: Independent effect of age, sex, group, and hypertension on level and change as estimated by multiple regressions of the level and change factors on these variables.

	HC		DLPFC		OF		VC		CD		CB		FW
	L	C	L	C	L	C	L	C	L	C	L	C	L	C
Age	−.64*	−.33	−.76*	−.02	−.80*	.31	−.52*	.11	−.77*	.22	−.63*	.02	−.67*	−.05
Sex	−.22	.00	−.16	−.10	−.04	−.03	−.08	.06	−.19*	.15	−.21*	.26	−.32*	−.06
Group	−.24	.06	−.08	.07	−.07	−.26	.01	−.19	.04	−.06	−.11	−.40*	−.09	.02
Hypertension	.09	−.10	−.10	−.09	−.08	−.36	.00	−.43	−.03	−.11	−.04	−.34*	−.09	.01

^*significant after Bonferroni adjustment (critical p=.007). Coefficients are standardized regression coefficients, and can be interpreted as correlations. Sex is coded as 1= man and 2 = women. Group 1=experimental and 2=control; Hypertension 0=normotensive and 1=hypertensive; L – level, C – change.

Abbreviations: HC – hippocampus, DLPFC – dorsolateral prefrontal cortex, OF – orbitofrontal cortex, VC – primary visual (pericalcarine) cortex, CD – caudate nucleus, CB – cerebellum, FW – prefrontal white matter.