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. Author manuscript; available in PMC: 2013 Sep 24.
Published in final edited form as: Drug Discov Today Technol. 2012 Sep 24;10(1):e129–e136. doi: 10.1016/j.ddtec.2012.09.005

Figure 4. Rescue of naïve courtship and memory by treatment with the mGluR antagonist MPEP.

Figure 4

Control (Rescue) and dfmr1 mutants (FS) were: A) raised in control food during development and adults (CT-CT); B) raised in food containing the mGluR antagonist MPEP (drug name) during development and as adults before testing (M-M); C) raised in MPEP containing food during development and then put on control food as adults before testing (M-CT); D) raised on control food during development and then placed on MPEP containing food during adulthood before testing. A) Treatment with only control food reveals the same dfmr1 phenotypes displayed in Figure 2, i.e. reduced naïve courtship and no detectable immediate recall memory. A–C) Treatment of the dfmr1 mutants with MPEP containing food during development and adulthood, development alone or adulthood alone, leads to significant rescue of the naïve courtship and memory deficits, indicated with asterisks, p<0.001.