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. 2013 Jun;182(6):2204–2213. doi: 10.1016/j.ajpath.2013.02.014

Figure 2.

Figure 2

B7h blockade significantly increases fetal resorption and reduces litter size in the CBA/CaJ×C57BL/6 allogeneic pregnancy model. A: Pregnant CBA/CaJ (×C57BL/6) females were injected intraperitoneally with anti-B7h mAb or control IgG, and the fetal resorption rate was determined at 13.5 dpc in pregnant CBA/CaJ mice of both groups. There was a significant increase in fetal resorption rate in the anti-B7h–treated mice, compared with control. B: Some mice treated with anti-B7h or rat control IgG were allowed to go to term and litter size was recorded. There was a significant reduction in litter size in the anti-B7h–treated mice, compared with control. n = 21 (A) or 11 (B), controls; n = 30 (A) or 12 (B), treatment group. Horizontal bars indicate means.