Figure 5.

Reduced litter size in CD4⁺ T-cell–deficient but not CD8⁺ T-cell–deficient mice after anti-B7h treatment. CD4⁺ (A) or CD8⁺ (B) T-cell–deficient females on C57BL/6 background were mated with CBA/CaJ males and treated with anti-B7h mAb or control IgG. Litter size was determined at term. There was a significant reduction in litter size in CD4-deficient mice but not in CD8-deficient mice. n = 8 or 9 per group. KO, knockout.