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. 2013 Jun;182(6):2332–2344. doi: 10.1016/j.ajpath.2013.02.031

Figure 4.

Figure 4

Stereology-based quantitative analysis of astrocytes double-labeled for GS and GFAP. The number of GS+GFAP+ astrocytes was higher in the AD group (E), whereas the number of GS+GFAP− astrocytes was higher in the nondemented group (C), but the number of total astrocytes did not differ significantly between AD patients and nondemented subjects (A). This phenotypic change paralleled the progression of the disease, but the number of total astrocytes remained essentially constant through its clinical course (B, D, and F). Counts in each case are not density measures, but estimates of the number of cells per 1 cm-long full-width cortex from a single section of temporal isocortex. Data are expressed as individual values with means ± SEM (A, C, and E) or 95% confidence interval of the mean slope (B, D, and F). ∗P < 0.0001.