Figure 7.

Association of the three microglial subpopulations with dense-core plaques and NFTs. The randomly selected microglial cells were categorized as close if located within 50 μm from the closest dense-core plaque or NFT, or as far if located more than 50 μm away from it. The three subsets of microglial cells are similarly attracted by the pathological hallmarks of AD and recruited toward them. Counts in each case are not density measures, but estimates of the number of cells per 1 cm-long full-width cortex from a single section of temporal isocortex. Counts close and far (from AD pathological hallmarks) from each of the 40 AD subjects are connected with lines. ^∗P < 0.0001.