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. 2013 Jun;182(6):2332–2344. doi: 10.1016/j.ajpath.2013.02.031

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© 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Effect of the APOE ɛ4 allele on microglial phenotype. Numbers of total microglia (A), IBA1⁺MHC2⁻ microglia (B), and IBA1⁻MHC2⁺ microglia (D) did not differ between APOE ɛ4 carriers and noncarriers. Only for IBA1⁺MHC2⁺ microglia (C) were numbers significantly higher in APOE ɛ4 carriers, compared with noncarriers. Counts in each case are not density measures, but estimates of the number of cells per 1 cm-long full-width cortex from a single section of temporal isocortex. Data are expressed as individual values with means ± SEM. ^∗P < 0.01.