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. 2013 Jun;182(6):1976–1985. doi: 10.1016/j.ajpath.2013.02.006

Figure 2.

Figure 2

Expression patterns of PPARα, PPARγ, and RXRα in mammary tissue and cancers from control and efatutazone-treated mice. Representative images of H&E-stained sections and PPARα, PPARγ, and RXRα IHC sections for each tissue shown. Small arrows indicate mammary epithelial ductal cell nuclei and large arrows indicate fat cell nuclei. Bar graphs summarize relative IHC scores for ductal epithelial (duct), fat (Fat), and cancer (Ca) cells. A: Mammary ductal structure and surrounding stromal fat pad (control). B: Undifferentiated adenocarcinoma (control). C: Undifferentiated spindloid cancer (control). D: Mammary ductal structure and surrounding stromal fat pad (efatutazone treated). E: Undifferentiated adenocarcinoma (efatutazone treated). F: Undifferentiated spindloid cancer (efatutazone treated). G: Papillary cancer (efatutazone treated). H: Adenosis (control). I: In situ carcinoma (control). IHC scores: 0 indicates no stain; 1, weak; 2, intermediate; and 3, strong. n = 10 (PPARγ and RXRα) and 5 (PPARα) control cancers; n = 8 (PPARγ and RXRα) and 5 (PPARα) efatutazone-treated cancers. Original magnification, ×40. Scale bars: 50 μm.