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. 2013 Jun;182(6):2082–2093. doi: 10.1016/j.ajpath.2013.02.010

Figure 3.

Figure 3

Prothrombin time (PT), partial thromboplastin time (PTT), and thrombin generation in Fut−/− mice. A and B: The time to initial fibrin formation via the extrinsic (A) or intrinsic (B) pathway was not altered in Fut−/− mice. C: Calibrated automated thrombography detects increased thrombin generation in WT mouse PPP spiked with prothrombin. D: Thrombin generation and activity were not different between WT and Fut−/− mice, respectively, as determined by lag time (4.1 ± 1.4 versus 3.8 ± 0.8 seconds; n = 5 per group, P = 0.73), maximum thrombin generation peak (21.8 ± 3.1 versus 21.5 ± 1 nmol/L; P = 0.93), time to maximum thrombin generation (9.4 ± 1.7 versus 8.7 ± 1.4 seconds; P = 0.44), or endogenous thrombin potential (326 ± 84 versus 269 ± 20; P = 0.18).