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. 2013 Jun;182(6):2241–2253. doi: 10.1016/j.ajpath.2013.02.011

Figure 3.

Figure 3

Atherosclerotic plaque size and total plaque burden does not differ between Col8+/+;ApoE−/− and Col8−/−;ApoE−/− mice. Representative longitudinal sections of aortic arches from Col8+/+;Apoe−/− and Col8−/−;Apoe−/− mice after 6 weeks (A) or 12 weeks (B) of an atherogenic diet. C: Plaque area was measured in the lesser curvature of the aortic arch after an atherogenic diet at 6 weeks in Col8+/+;ApoE−/− (n = 13) and Col8−/−;ApoE−/− (n = 17) mice or at 12 weeks in Col8+/+;ApoE−/− (n = 13) and Col8−/−;ApoE−/− (n = 15) mice. D: Plaque area was measured in the brachiocephalic artery at 6 weeks in Col8+/+;Apoe−/− (n = 8) and Col8−/−;ApoE−/− (n = 12) mice or at 12 weeks in Col8+/+;ApoE−/− (n = 11) and Col8−/−;ApoE−/− (n = 6) mice. E: Plaque area was measured in the left common carotid artery at 6 weeks in Col8+/+;ApoE−/− (n = 9) and Col8−/−;ApoE−/− (n = 9) mice or at 12 weeks in Col8+/+;Apoe−/− (n = 10) and Col8−/−;ApoE−/− (n = 6) mice. Horizontal lines indicate the group mean. F: The percentage of descending aorta surface area occupied by plaque was measured at 6 weeks in Col8+/+;ApoE−/− (n = 14) and Col8−/−;Apoe−/− (n = 13) mice or at 12 weeks in Col8+/+;ApoE−/− (n = 11) and Col8−/−;ApoE−/− (n = 16) mice. Black bars represent values from Col8+/+;ApoE−/− mice, and hatched bars represent values from Col8−/−;ApoE−/− mice. Values are given as means ± SEM. Scale bars: 100 μm.