Table 1.
List of Proteins Measured
| Proteins Different Among APOE Genotype Groupsa | Proteins With Interaction Between APOE Genotype and FAD Mutation Status | Proteins Measured in >50% of Casesb | ||
|---|---|---|---|---|
| Apolipoprotein E | Apolipoprotein E | Adiponectin | GRO-α | MIP-1α |
| AXL | AXL receptor tyrosine kinase | Agouti-related protein | HCC-4 | MIP-1β |
| BDNF | IGF-1 | Angiopoietin 2 | Hepatocyte growth factor | NrCAM |
| CD5L | Thrombopoietin | Apolipoprotein B | ICAM-1 | Protein S |
| CgA | Fas ligand | Apolipoprotein D | IGF BP-2 | Pulmonary and activation-regulated chemokine |
| EGF | MDC | Apolipoprotein J (clusterin) | IGF-1 | S100β |
| Basic FGF | IL-1α | β-Lymphocyte chemoattractant | IL-16 | SGOT |
| I-309 (CCL1) | IL-7 | Betacellulin | IL-1α | Sortilin |
| IL-12p40 | IL-12p40 | BMP-6 | IL-1β | sRAGE |
| IL-13 | IL-13 | Ciliary neurotrophic factor | IL-7 | Stem cell factor |
| IL-3 | IL-3 | Complement factor H | IL-8 | Thrombopoietin |
| IL-4 | IL-4 | ENA-78 | Insulin | Thymus-expressed chemokine |
| IL-5 | IL-5 | Eotaxin-3 | M-CSF | TIMP-2 |
| IL-15 | Fas | MCP-1 | TRAIL-R3 | |
| RANTES | Fas ligand | MCP-3 | VEGF | |
| Superoxide dismutase 1 | Fetuin A | MDC | Vitronectin | |
| TIMP-1 | FGF-4 | MIF | ||
Abbreviations: AXL, AXL receptor tyrosine kinase; BDNF, brain-derived neurotrophic factor; BMP-6, bone morphogenetic protein 6; CCL1, CC chemokine 1; CD5L, CD5 antigen–like; CgA, chromogranin A; EGF, epidermal growth factor; FAD, familial Alzheimer disease; FGF, fibroblast growth factor; ICAM-1, intracellular adhesion molecule 1; IGF-1, insulinlike growth factor 1; IGF BP-2, insulinlike growth factor binding protein 2; IL, interleukin; M-CSF, macrophage colony-stimulating factor; MDC, macrophage-derived chemokine; MIF, macrophage migration inhibitory factor; MIP-1, macrophage inflammatory protein 1; NrCAM, neuronal cell adhesion molecule; SGOT, serum glutamic oxaloacetic transaminase; sRAGE, receptor for advanced glycosylation end products; TIMP-1/-2, tissue inhibitor of metalloproteinase 1 and 2; TRAIL-R3, TNF-related apoptosis-inducing ligand receptor 3; VEGF, vascular endothelial growth factor.
Differences analyzed by Kruskal-Wallis test (P < .05, false discovery rate < 0.2).
There was no differentiation between FAD mutation carriers and noncarriers, nor among APOE genotype group.