Table 2.
Subgroup analyses of percentages of patients still positive for viral RNA at day five of treatment in samples taken from nose. Patients grouped according to age, detected virus, and day of illness on enrolment
| Standard dose | Double dose | P value‡ | ||||||
|---|---|---|---|---|---|---|---|---|
| No* (%) | Copy number (range)† | No with positive quantitative RT-PCR result | No* (%) | Copy number (range)† | No with positive quantitative RT-PCR result | |||
| Age groups | ||||||||
| All | 22/143 (15.4) | 4.33e+03 (1.00e+03-7.40e+04) | 8 | 22/150 (14.7) | 2.94e+03 (1.00e+03-5.62e+04) | 9 | 0.85 | |
| <18 | 20/116 (17.2) | 4.97e+03 (1.00e+03-7.40e+04) | 7 | 19/120 (15.8) | 2.88e+03 (1.00e+03-4.62e+04) | 0.77 | ||
| 0-4 | 17/105 (16.2) | 1.45e+04 (2.55e+03-7.40e+04) | 6 | 18/106 (17) | 2.88e+03 (1.00e+03-4.62e+04) | 8 | 0.88 | |
| 5-17 | 3/11 (27.3) | 1.00e+03 (1.00e+03-1.00e+03) | 1 | 1/14 (7.1) | — | 0 | 0.17 | |
| ≥18 | 2/27 (7.4) | 1.35e+03 (1.35e+03-1.35e+03) | 1 | 3/30 (10) | 5.62e+04 (5.62e+04-5.62e+04) | 1 | 0.76 | |
| 18-59 | 0/17 (0) | — | 0 | 3/28 (10.7) | 5.62e+04 (5.62e+04-5.62e+04) | 1 | 0.17 | |
| ≥60 | 2/10 (20) | 1.35e+03 (1.35e+03-1.35e+03) | 1 | 0/2 (0) | — | 0 | 0.49 | |
| Virus type | ||||||||
| 1977 H1N1 | 2/23 (8.7) | 4.97e+03 (4.97e+03-4.97e+03) | 1 | 3/13 (23.1) | — | 0 | 0.23 | |
| H3N2 | 13/61 (21.3) | 3.68e+03 (1.35e+03-2.64e+04) | 5 | 12/70 (17.1) | 8.93e+03 (1.04e+03-4.62e+04) | 5 | 0.54 | |
| H1N1-pdm09 | 2/34 (5.9) | — | 0 | 2/36 (5.6) | 2.94e+03 (2.94e+03-2.94e+03) | 1 | 0.95 | |
| H5N1 | 0/0 (0) | — | 0 | 1/4 (25) | 5.62e+04 (5.62e+04-5.62e+04) | 1 | ||
| B | 5/25 (20) | 3.75e+04 (1.00e+03-7.40e+04) | 2 | 4/27 (14.8) | 1.00e+03 (1.00e+03-1.00e+03) | 2 | 0.62 | |
| Time to treatment (days from onset of illness) | ||||||||
| Within 2 | 4/17 (23.5) | 1.33e+04 (2.55e+03-2.40e+04) | 2 | 6/14 (42.9) | 2.94e+03 (2.82e+03-4.62e+04) | 3 | 0.25 | |
| Within 3 | 6/38 (15.8) | 1.33e+04 (2.55e+03-2.40e+04) | 2 | 10/33 (30.3) | 2.94e+03 (1.04e+03-4.62e+04) | 5 | 0.14 | |
| Within 4 | 12/64 (18.8) | 1.33e+04 (1.35e+03-7.40e+04) | 4 | 14/59 (23.7) | 5.94e+03 (1.04e+03-4.62e+04) | 6 | 0.50 | |
| >4 | 10/79 (12.7) | 4.33e+03 (1.00e+03-2.64e+04) | 4 | 7/91 (7.7) | 2.86e+04 (1.00e+03-5.62e+04) | 2 | ||
RT-PCR=reverse transcriptase polymerase chain reaction.
*Patients still positive by qualitative RT-PCR in each arm per subgroup.
†Calculated from results of quantitative RT-PCR.
‡From χ2 for comparison of number of patients still positive by qualitative RT-PCR in each arm.